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Sickle Cell Anemia

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SCI260 – Introduction to Biochemistry

Lesson 2

During tonight’s class, we discussed protein structure and how changes in the amino

acid sequence of a protein can significantly alter its function and cause

diseases/disorders. With this in mind, write a paragraph that explains the cause of

sickle cell anemia disease?

Your answer should be no longer than one page and should answer ALL of the following


1. What is the name (spell it out) of the specific protein that is affected in sickle cell

anemia disease?

2. Describe the specific change in the amino acid sequence that causes sickle cell

anemia disease?

3. How does this protein function in normal people who do not suffer from sickle cell

anemia disease?

4. What are the symptoms that individuals with sickle cell anemia disease experience?

5. Is there a cure for sickle cells anemia disease? If not, describe the types of

treatments that are used to alleviate the symptoms of sickle anemia disease.

You will earn 20 pts for correctly answering each question (maximum points earned is

100). You may use the internet and/or your textbook to assist you, but please DO NOT

copy your answers directly from the internet or textbook.

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